Journal: European Radiology

Article Title: Association of layer-specific knee cartilage T2-relaxation measurements with age, sex and cartilage morphology at 1.5-T MRI

doi: 10.1007/s00330-025-11806-8

Figure Lengend Snippet: Sagittal multi-slice multi-echo spin-echo sequence (MSME-SE) with the lowest acquired echo time (13.8 ms) showing the defined joint compartments. Additionally plotted long and short axis within the ROI (blue lines) for automatic calculation of the ROI area. a Central and posterior lateral femoral condyle (cLF, pLF), lateral tibia (LT). b Central and posterior medial femoral condyle (cMF, pMF), medial tibia (MT). c Retropatellar cartilage (P). Source: study participant from the SHIP-TREND-1 data pool

Article Snippet: A sagittal 2D T2-weighted MSME with automatic inline calculation of parametric, color-coded T2-maps by the built-in MapIt (version 1.0 Siemens Healthineers) was used for cartilage T2 measurements.

Techniques: Sequencing

Journal: European Radiology

Article Title: Association of layer-specific knee cartilage T2-relaxation measurements with age, sex and cartilage morphology at 1.5-T MRI

doi: 10.1007/s00330-025-11806-8

Figure Lengend Snippet: Sagittal T2-map MSME-SE sequence in rainbow color scheme showing manually created total ROI at lateral tibia ( A , outlined in red) and program function generated subdivision into deep ( B ) and superficial cartilage layer ( C ) (outlined in red). Chemical artifact at the bone-cartilage interface with single pixels of high intensity (arrow in A ). Source: study participant from the SHIP-TREND-1 data pool

Article Snippet: A sagittal 2D T2-weighted MSME with automatic inline calculation of parametric, color-coded T2-maps by the built-in MapIt (version 1.0 Siemens Healthineers) was used for cartilage T2 measurements.

Techniques: Sequencing, Generated

Journal: European Radiology

Article Title: Magnetic resonance fingerprinting for the whole knee articular cartilage assessment using automated pipeline

doi: 10.1007/s00330-025-11825-5

Figure Lengend Snippet: Steps of the automated pipeline. (Top row) DESS images were used for automatic segmentation of the cartilage in the MR ChondralHealth software. Subsequently, DESS images, segmentation and MSME and MRF T2 maps were loaded to 3D Slicer. Both T2 maps were registered and resampled to DESS images, and segmentation was overlaid on the resulting images. Extreme values were masked out, and mean T2 values for each segment were extracted for further analysis

Article Snippet: A conventional MSME sequence optimized for cartilage T2 mapping evaluation (MapIt, Siemens Healthineers AG) was acquired for comparison.

Techniques: Software

Journal: European Radiology

Article Title: Magnetic resonance fingerprinting for the whole knee articular cartilage assessment using automated pipeline

doi: 10.1007/s00330-025-11825-5

Figure Lengend Snippet: FS TSE PD image showing a cartilage lesion identified by an experienced MSK radiologist ( A ), guiding lesion segmentation within the automatic cartilage segmentation mask ( B ). Corresponding slices of MSME ( C ) and MRF ( D ) cartilage T2 maps with the lesion

Article Snippet: A conventional MSME sequence optimized for cartilage T2 mapping evaluation (MapIt, Siemens Healthineers AG) was acquired for comparison.

Techniques:

Journal: European Radiology

Article Title: Magnetic resonance fingerprinting for the whole knee articular cartilage assessment using automated pipeline

doi: 10.1007/s00330-025-11825-5

Figure Lengend Snippet: A Representative MSME (top) and MRF (bottom) T2 maps. B Mean MSME, MRF, and reference T2 values measured in individual samples of the NIST phantom. Gray area marks the analyzed range of the NIST phantom, which corresponds to cartilage T2 values. C Correlation and ( D ) Bland–Altman plot between MSME and MRF T2 values from samples No. 6 to 10

Article Snippet: A conventional MSME sequence optimized for cartilage T2 mapping evaluation (MapIt, Siemens Healthineers AG) was acquired for comparison.

Techniques:

Journal: European Radiology

Article Title: Magnetic resonance fingerprinting for the whole knee articular cartilage assessment using automated pipeline

doi: 10.1007/s00330-025-11825-5

Figure Lengend Snippet: Mean T2 values with inter-quartile range of all segments in the volunteer and patient groups measured by the MSME and MRF methods

Article Snippet: A conventional MSME sequence optimized for cartilage T2 mapping evaluation (MapIt, Siemens Healthineers AG) was acquired for comparison.

Techniques:

Journal: European Radiology

Article Title: Magnetic resonance fingerprinting for the whole knee articular cartilage assessment using automated pipeline

doi: 10.1007/s00330-025-11825-5

Figure Lengend Snippet: Scatterplots depicting linear correlation between T2 values measured by MSME and MRF for the volunteer and patient groups

Article Snippet: A conventional MSME sequence optimized for cartilage T2 mapping evaluation (MapIt, Siemens Healthineers AG) was acquired for comparison.

Techniques:

Journal: Scientific Reports

Article Title: Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness

doi: 10.1038/s41598-019-47905-y

Figure Lengend Snippet: Msmeg in vitro growth requirement analysis. ( a ) Transposon insertion counts across the Msmeg genome (Middlebrook 7H10-selected library). The height of the black bars represents the number of insertion counts at the respective genome site. ( b ) Definition of the Msmeg wt in vitro requirement for growth (Middlebrook 7H10-selected library). 5815 genes were identified as non-essential (NE) for growth, 415 as causing growth advantage when disrupted (GA), 306 as essential (ES), and 97 as causing growth defect when disrupted (GD). 83 genes were not defined. ( c ) Venn diagram illustrating Msmeg required genes (ES and GD) and Mtb required genes (ES, GD and ESD, the latter genes with essential domains) as defined by DeJesus et al . , relative to the entire pool of Msmeg (6716) and Mtb (4019) genes and their mutual orthologs (2547). Msmeg (403) and Mtb (625) required genes are shown within the blue and red circle, respectively. 343 genes are required in both species, 44 ( Msmeg ) and 247 ( Mtb ) required genes have a non-required mutual ortholog in the other species, and 16 ( Msmeg ) and 35 ( Mtb ) required genes do not have mutual orthologs in the other species ( d ) Venn diagram illustrating Msmeg and Mtb GA (causing growth advantage when disrupted) genes, as described for ( c ). Msmeg (415) and Mtb (283) GA genes are shown within the blue and red circle, respectively. 27 genes cause growth advantage in both species, 121 ( Msmeg ) and 123 ( Mtb ) GA genes have a non-GA mutual ortholog in the other species, and 267 ( Msmeg ) and 160 ( Mtb ) GA genes do not have mutual orthologs in the other species.

Article Snippet: Furthermore, genes within the esx-3 gene cluster, required for mycobactin-mediated iron uptake, are essential in Mtb when cultured in standard (Middlebrook 7H10) medium but dispensable in Msmeg grown under similar conditions , .

Techniques: In Vitro